litaba

Cetylpyridinium chloride joalo ka Phekolo ea COVID-19

Teko e bonts'a maqhubu a phahameng a li-quaternary ammonium disinfectants e le kalafo bakeng sa livaerase tse ngata, ho kenyeletsoa le coronaviruses: tsena li etsa ka ho thibela liphahlo tse sireletsang tse nang le lipilisi tse koahelang likokoana-hloko tse kang SARS-CoV-2. Metsoako ea quaternary ammonium e khothaletsoa ka bongata ho bolaea likokoana-hloko 'me ho na le lihlahisoa tse fetang 350 Lethathamong la EPA la N: Likokoana-hloko tse ka sebelisoang khahlano le SARS-CoV-2 (Supplementary Material. lik'hemik'hale tse lenaneng la EPA li tlalehiloe mme> 140 e ka thibela vaerase ka metsotso e seng mekae feela (18).
Tlhahisoleseling ena e re lebisitse phuputsong e kholo ea metsoako ea ammonium e nang le ts'ebetso khahlanong le li-coronaviruses le ho tsebahala ha lik'hemik'hale tse seng li lekile tleliniking mme li ka sebelisoa e le kalafo e ka bang teng ea COVID-19. E 'ngoe ea likokoana-hloko tse bontšitsoeng li senya likokoana-hloko (Supplementary Material)' me li sebelisoa haholo lihlahisoa tsa tlhokomelo ea motho ke cetylpyridinium chloride. Motsoako ona o fumanoa haholo ka metsing a hlatsoang molomo 'me o thathamisitsoe ke FDA ka kakaretso e nkuoa e le Sireletsehile (GRAS) joalo ka hore e ntse e sebelisoa joalo ka moemeli oa lithibela-mafu bakeng sa lihlahisoa tsa nama le likhoho (ho fihlela ho 1%). Cetylpyridinium chloride e sebelisitsoe litekong tse ngata tsa kliniki, ho kenyelletsa kalafo khahlano le tšoaetso ea phefumoloho e netefatsang ts'ebeliso ea eona e le antiviral. Cetylpyridinium e kanna ea khothalletsa ho se sebetse ha vaerase ka ho senya capid le ka ts'ebetso ea eona ea lysosomotropic, eo, joalo ka ha ho boletsoe kaholimo, e tloaelehileng bakeng sa metsoako ea quaternary ammonium. Sena se hlahisa potso ea hore na meriana e meng e khethiloeng ka li-antiviral khahlanong le SARS-CoV-2 in vitro e sebetsa ka tsela e ts'oanang, e leng hore e ka senya vaerase ea capid le ho bokella lysosome kapa endosomes mme qetellong e thibele ho kenella ha vaerase. Liphuputso tse ling tse phatlalalitsoeng li bontšitse hore phello ena e ka fokotsoa ka ts'ebeliso ea Cathepsin-L inhibitors. 

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Cetylpyridinium chloride (CPC)

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Li-quaternary ammonium compounds tse nang le ts'ebetso e tsebahalang ea coronavirus

Molek'hule

Mosebetsi o thibelang likokoana-hloko

Mokhoa

Ho amoheloa ke FDA

Sebelisa

Chloride ea Ammonium Murine coronavirus, hepatitis C, Lysosomotropic Ho joalo Lits'ebeliso tse fapaneng ho kenyelletsa metabolism ea metabolic.
Cetylpyridinium chloride Mokakallane, lefu la sebete la mofuta oa B, poliovirus 1 Lits'oants'o tsa capsid ebile ke lysosomotropic Ee, GRAS Likokoana-hloko, ho hlatsoa molomo, ho khohlela, lihlahisoa tsa tlhokomelo ea motho, lisebelisoa tsa ho hloekisa jj

Nako ea poso: Apr-16-2021